Latency of varicella zoster virus a persistently perplexing state

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Latency of varicella zoster virus; a persistently perplexing state.

Varicella zoster virus (VZV) is the herpesvirus which causes the childhood disease varicella, also known as chickenpox, and the adult disease herpes zoster, also known as shingles. These distinct diseases are separated by a lengthy period of latency, often lasting decades, in which the virus resides within the ganglia of the host. VZV latency and reactivation from it have, for the most part, be...

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Key issues in varicella-zoster virus latency.

The molecular mechanisms by which varicella-zoster virus (VZV) causes a latent infection in human trigeminal and spinal ganglia are not well understood. It is known that VZV establishes latency in ganglia following the primary infection causing varicella (chickenpox), and that the virus may reactivate after years of dormancy to produce herpes zoster (shingles). Two key issues have been the cell...

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Covid-19 Vaccination and Reactivation of Varicella Zoster Virus

Introduction: After COVID-19 pandemic in 2020 that mostly affects upper respiratory tract, the scientists investigated an effective vaccine against the virus. As the vaccination of general population started some patients were visited with varicella zoster virus activation following the COVID vaccine.

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Varicella zoster virus.

Because of its ability to produce two clinically distinct disease entities (chickenpox and shingles), varicella zoster virus (VZV) is an unusual etiologic agent. Although in the past viral exanthems were mostly only of academic interest to the practitioner, the development of antiviral agents and the newly approved varicella (OKA) vaccine have increased the clinical significance. Also, with the...

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ژورنال

عنوان ژورنال: Frontiers in Bioscience

سال: 1999

ISSN: 1093-9946,1093-4715

DOI: 10.2741/a422